Synthesis and properties of isoviagra. A 2??methyl??2H??pyrazolo [4, 3??d] pyrirnidin??7??one isomer of viagra®

MM El??Abadelah, SS Sabri, MA Khanfar…

Index: El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059

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Citation Number: 9

Abstract

Abstract The synthesis and spectral properties (ir, ms, nmr) of a substituted 2-methyl-2H- pyrazolo [4, 3-d]-pyrimidin-7-one (3), an isomer of Viagra®, are described. The key synthon, 4-amino-1-methyl-5-propyl-3-pyrazolecarboxamide (7), is prepared via the reaction of ethyl 2, 4-dioxoheptanoate with methylhydrazine, followed by cyclization, nitration, amidation, and nitro group reduction. Interaction of 7 with 2-ethoxyben-zoyl chloride yielded the ...