Tetrahedron

Chiral β-amino sulfoxides. Synthesis, configurational assignment and conformational analysis based on X-ray, CD, 1 H NMR and theoretical calculations

A Lewanowicz, J Lipiński, R Siedlecka, J Skarżewski…

Index: Lewanowicz; Lipinski; Siedlecka; Skarzewski; Baert Tetrahedron, 1998 , vol. 54, # 23 p. 6571 - 6586

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Citation Number: 23

Abstract

Enantiomerically pure u and l β-amino sulfoxides have been easily obtained from the respective homochiral α-amino alcohols. The absolute configuration at the created stereogenic centre was assigned by CD spectra and by X-ray analysis. Conformational analysis of the title compounds was carried out using quantum chemical energy-geometry optimization. Thus established conformational behavior explained the strongly ...