Enzymatic desymmetrization of prochiral 2-benzyl-1, 3-propanediol derivatives: A practical chemoenzymatic synthesis of novel phosphorylated tyrosine analogues
T Yokomatsu, T Minowa, T Murano, S Shibuya
Index: Yokomatsu, Tsutomu; Minowa, Takayuki; Murano, Tetsuo; Shibuya, Shiroshi Tetrahedron, 1998 , vol. 54, # 32 p. 9341 - 9356
Full Text: HTML
Citation Number: 33
Abstract
(Phosphonomethyl) phenylalanine (Pmp) and (phosphonodifluoromethyl) phenylalanine (F2Pmp) as well as their β-amino acid congeners were prepared as a protecting variant amenable to the peptide synthesis from readily available 2-benzyl-1, 3-propandiols possessing either a diethylphosphonomethyl-or diethylphosphonodifluoromethyl functionality at the para-position via the lipase-catalyzed desymmetrization.
Related Articles:
[Liu, Wang-Qing; Roques, Bernard P.; Garbay, Christiane Tetrahedron Letters, 1997 , vol. 38, # 8 p. 1389 - 1392]
[Solas, Dennis; Hale, Ron L.; Patel, Dinesh V. Journal of Organic Chemistry, 1996 , vol. 61, # 4 p. 1537 - 1539]
[Solas, Dennis; Hale, Ron L.; Patel, Dinesh V. Journal of Organic Chemistry, 1996 , vol. 61, # 4 p. 1537 - 1539]
[Liu, Wang-Qing; Roques, Bernard P.; Garbay, Christiane Tetrahedron Letters, 1997 , vol. 38, # 8 p. 1389 - 1392]
[Liu, Wang-Qing; Roques, Bernard P.; Garbay, Christiane Tetrahedron Letters, 1997 , vol. 38, # 8 p. 1389 - 1392]