Reaction of mixed carboxylic anhydrides with grignard reagents: Application to the preparation of keto esters; scope and limitations

T Terasawa, T Okada

Index: Terasawa,T.; Okada,T. Tetrahedron, 1977 , vol. 33, p. 595 - 598

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Citation Number: 13

Abstract

The low-temperature Grignard reaction of mixed carboxylic anhydrides derived from acid chlorides and o-anisic acid to the general synthesis of keto esters is demonstrated for compounds 1–6, although, some limitations on substrate and Grignard reagent species are also encountered; attempts in the oxa series 2 are unsuccessful, and reaction with ω- phenylpropyl Grignard species for 1 and 4 shows a drastic decrease in yields of the keto ...