An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl) naphthalen-2-yl)-5-((2, 2-methylpropyl) carbamoyl) benzoic acid: a factor VIIa inhibitor discovered by the …

…, KJ Filipski, ST Rapundalo, WL Cody, JJ Edmunds

Index: Kohrt; Filipski; Rapundalo; Cody; Edmunds Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6041 - 6044

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Citation Number: 38

Abstract

It is the abnormal coagulation and inappropriate thrombus formation within blood vessels that precipitates many acute cardiovascular diseases. As a result, there has been an intense effort to discover small molecule anticoagulants that work to specifically inhibit serine proteases in the blood coagulation cascade. The direct inhibition of thrombin has been intensively investigated leading to the development of potent and selective inhibitors, but clinical trials have met ...