Synthesis and structure–activity relationships of ferrocenyl tamoxifen derivatives with modified side chains

A Nguyen, S Top, P Pigeon, A Vessières…

Index: Nguyen, Anh; Top, Siden; Pigeon, Pascal; Vessieres, Anne; Hillard, Elizabeth A.; Plamont, Marie-Aude; Huche, Michel; Rigamonti, Clara; Jaouen, Gerard Chemistry - A European Journal, 2009 , vol. 15, # 3 p. 684 - 696

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Citation Number: 52

Abstract

Abstract We report here the synthesis and cell-proliferation properties of derivatives of the breast cancer drug tamoxifen, in which the [BOND] O (CH 2) 2 N (CH 3) 2 side chain, responsible for the drug's antiestrogenic properties, has been modified by a ferrocenyl moiety. We recently reported the diphenol compound 5, in which this amino chain had been replaced with an acyl-ferrocenyl ([BOND] O (CH 2) 2 C (O)[(η 5-C 5 H 4) FeCp]) group, ...