New multi-coupling benzylic zinc reagents for the preparation of flexible aromatic compounds
M Rottländer, P Knochel
Index: Rottlaender, Mario; Knochel, Paul Tetrahedron Letters, 1997 , vol. 38, # 10 p. 1749 - 1752
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Citation Number: 28
Abstract
The benzylic zinc reagents 3a-c bearing a triflate group in o-, m-or p-position are new efficient multi-coupling reagents reacting stepwise with an aryl iodide (Ar1 I) and an arylzinc bromide (Ar2ZnBr) in the presence of the appropriate palladium catalyst and the suitable phosphine ligand leading to polyfunctional flexible aromatic products of type 5. This methodology is appropriate for applications in combinatorial chemistry.
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