SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents

F Gigante, M Kaiser, R Brun, IH Gilbert

Index: Gigante, Federica; Kaiser, Marcel; Brun, Reto; Gilbert, Ian H. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 16 p. 5950 - 5961

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Citation Number: 23

Abstract

There is an urgent need for the development of new drugs for the treatment of neglected tropical diseases such as human African trypanosomiasis, Chagas disease and leishmaniasis. Azasterols, have been shown to have activity against the parasites which cause these diseases. In this paper we report synthesis of new azasterols and subsequent analysis of the SAR. The chemistry focused on variations in the ester at the 3β-position of ...