Efficient asymmetric hydrogenation of pyridines

…, N Spielkamp, S Holle, R Goddard…

Index: Glorius, Frank; Spielkamp, Nick; Holle, Sigrid; Goddard, Richard; Lehmann, Christian W. Angewandte Chemie - International Edition, 2004 , vol. 43, # 21 p. 2850 - 2852

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Citation Number: 136

Abstract

Catalytic asymmetric hydrogenation has become a key technology in academic research [1] and in industry [2] owing to its generally unrivalled efficiency and selectivity.[3] Nevertheless, no satisfactory solution for the asymmetric hydrogenation of aromatic or heteroaromatic substrates according to Scheme 1 exists,[4] although these compounds are readily available and the reaction has the potential for the simultaneous creation of multiple stereocenters. ...