Tetrahedron letters

Efficient, protection-free Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles

N Cousaert, P Toto, N Willand, B Deprez

Index: Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit Tetrahedron Letters, 2005 , vol. 46, # 38 p. 6529 - 6532

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Citation Number: 12

Abstract

We describe an efficient protocol for the Suzuki–Miyaura synthesis of ortho- biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1, 1′-bis (diphenylphosphino) ferrocene] dichloropalladium (II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure.