Tetrahedron Letters

Synthesis and stereochemistry of cis-2, 6-diphenyl-1-alkylpiperidines

HSP Rao, E Poonguzhali

Index: Rao, H. Surya Prakash; Bharathi; Jeyalakshmi Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997 , vol. 36, # 7 p. 557 - 561

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Abstract

Abstract Facile and efficient synthesis of N-alkyl-2, 6-diphenylpiperidines (NADPPs) was achieved by reductive amination cyclization (RAC) reaction on 1, 5-diketones using alkylammonium formate. The reaction is a useful extension of classical Leuckart reductive