Tetrahedron letters

Confirmation and prevention of halogen exchange: practical and highly efficient one-pot synthesis of dibromo-and dichloropyridazinones

J Zhang, HE Morton, J Ji

Index: Zhang, Ji; Morton, Howard E.; Ji, Jianguo Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735

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Citation Number: 21

Abstract

Commercially available anilines were converted by a two step, one-pot process to the corresponding pyridazinones in good to excellent yields. During the process research, a significant halogen exchange was confirmed and prevented which allowed the process to be scaled to multikilogram quantities.