Pyrazolothiazolopyrimidine derivatives as a novel class of anti-inflammatory or antinociceptive agents: synthesis, structural characterization and pharmacological …

F Russo, S Guccione, G Romeo, GU Barretta…

Index: Russo, F; Guccione, S; Romeo, G; Barretta, G Uccello; Pucci, S; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 363 - 376

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Citation Number: 36

Abstract

Abstract As a part of a research program on anti-inflammatory-analgesic compounds, pyrazolothiazolopyrimidines 5a-f and 5g-i were prepared by cyclodehydration in 98% H 2 SO 4 or PPA of the corresponding 6-thioketomethylene-substituted-4-hydroxy-pyrazolo [3, 4- d] pyrimidines 2a-i and 2g-i. The results of the pharmacological in vivo screening indicate an interesting dissociation of the analgesic from the anti-inflammatory activity depending on ...