Enantiomerically Pure [1, 2??Diamino??1??(4??fluorophenyl) butane] platinum (II) Complexes: Synthesis and Antitumor Activity against MCF??7 and MDA??MB 231 Breast …
A Dullin, F Dufrasne, M Gelbcke…
Index: Dullin, Anja; Dufrasne, Francois; Gelbcke, Michael; Gust, Ronald Archiv der Pharmazie, 2004 , vol. 337, # 12 p. 654 - 667
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Citation Number: 18
Abstract
Abstract Enantiomerically pure 1, 2-diamino-1-(4-fluorophenyl) butanes were synthesized by stereoselective procedures. The enantiomeric purity was determined by 1 H NMR spectroscopy after derivatization with (1R)-myrtenal. For the coordination to platinum, the diamines were reacted with K 2 PtI 4. Reaction with Ag 2 SO 4 yielded the respective sulfatoplatinum (II) complexes, which were converted into the dichloroplatinum (II) ...
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