Il Farmaco

Substituted 5-aroylpyrazine-2-carboxylic acid derivatives: synthesis and biological activity

M Dolezal, J Jampılek, Z Osicka, J Kuneš, V Buchta…

Index: Dolezal; Jampilek; Osicka; Kunes; Buchta; Vichova Farmaco, 2003 , vol. 58, # 11 p. 1105 - 1111

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Citation Number: 34

Abstract

Homolytic aroylation of pyrazine nucleus with various substituted aromatic carbaldehydes afforded a series of 5-aroylpyrazine-2-carboxylic acid derivatives. The synthetic approach, analytical and spectroscopic data of all compounds synthesized, their preliminary in vitro evaluation of antituberculotic and antifungal activities, cytotoxicity data and subsequent SAR studies are presented. Among all derivatives prepared, only 5-(4-chlorobenzoyl)-pyrazine- ...