Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives
AJ Hoefnagel, H van Koningsveld, F van Meurs…
Index: Hoefnagel; Van Koningsveld; Van Meurs; Peters; Sinnema; Van Bekkum Tetrahedron, 1993 , vol. 49, # 31 p. 6899 - 6912
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Citation Number: 13
Abstract
Reaction of hydroxyglycine with 2-aminobenzophenones gives 1, 2-dihydro-4-phenyl- quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3, 4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1, 2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows ...
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Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives
[Tetrahedron, , vol. 49, # 31 p. 6899 - 6912]
Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives
[Tetrahedron, , vol. 49, # 31 p. 6899 - 6912]