Rapid synthesis of aliphatic amides by reaction of carboxylic acids, Grignard reagent and amines: application to the preparation of [11 C] amides

C Aubert, C Huard-Perrio, MC Lasne

Index: Aubert, Catherine; Huard-Perrio, Cecile; Lasne, Marie-Claire Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2837 - 2842

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Citation Number: 21

Abstract

Aliphatic amides have been prepared in moderate to good yields (30–70%) by treatment in THF of magnesium halide carboxylates with amines in the presence of 2.5 equivalents of alkylmagnesium halide. The reaction is rapid (< 30 min) and has been successfully applied to the synthesis of amides labelled with carbon-11 (β+, t½: 20.4 min).[11C] Aliphatic amides have been obtained in 15–60% radiochemical yields [decay corrected to end of ...