Synthesis of potential C27-intermediates in bile acid biosynthesis and their deuterium-labeled analogs

J Shoda, M Axelson, J Sjövall

Index: Shoda, Junichi; Axelson, Magnus; Sjoevall, Jan Steroids, 1993 , vol. 58, # 3 p. 119 - 125

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Citation Number: 40

Abstract

Abstract In connection with studies of alternative pathways in bile acid biosynthesis, potential intermediates in a pathway starting with 27-hydroxylation of cholesterol have been prepared in natural and deuterated forms. Established methods were used to prepare 27- hydroxycholesterol and 3β-hydroxy-5-cholestenoic acid. Clemmensen reduction of kryptogenin in unlabeled and deuterated solvents yielded 27-hydroxy-cholesterol and 16- ...