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The synthesis of pyrimidine 1-oxides: a new transformation of amide oximes

M Kočevar, B Mlakar, M Perdih, A Petrič, S Polanc…

Index: Kocevar; Mlakar; Perdih; Petric; Polanc; Vercek Tetrahedron Letters, 1992 , vol. 33, # 16 p. 2195 - 2198

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Citation Number: 10

Abstract

Typical procedure: Appropriate solvent (25 ml, Table) was treated at room temperature with catalyst (7.5–10 mmol), followed by the addition of the corresponding C 3 synthon 2 – 5 (7.5 mmol) and carboxamide oxime 1 (7.2 mmol). Reaction mixture was heated under reflux, evaporated to dryness, dissolved in water, neutralized with sodium carbonate, extracted with chloroform, dried over anhydrous sodium sulfate and evaporated to dryness. Pyrimidine 1-oxides have ...