Tetrahedron letters

A new flourene-derived anchor for solid-phase synthesis of protected peptides

F Rabanal, E Giralt, F Albericio

Index: Rabanal, Francesc; Giralt, Ernest; Albericio, Fernando Tetrahedron Letters, 1992 , vol. 33, # 13 p. 1775 - 1778

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Citation Number: 27

Abstract

Abstract N-[9-(hydroxymethyl)-2-fluorenyl succinamic acid may be used as an anchoring linkage for the preparation of protected peptide segments in combination with Boc/Bzl 1 protection scheme. The new handle proved to be stable to the usual conditions of solid- phase peptide synthesis and gave the protected peptide in high yields and purities by treatment with piperidine or morpholine.