Asymmetric, Regioselective Bromohydroxylation of 2??Aryl??2??propen??1??ols Catalyzed by Quinine??Derived Catalysts

Y Zhang, H Xing, W Xie, X Wan, Y Lai…

Index: Zhang, Ye; Xing, Hui; Xie, Weiqing; Wan, Xiaolong; Lai, Yisheng; Ma, Dawei Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 68 - 72

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Citation Number: 24

Abstract

Abstract The asymmetric bromohydroxylation of 2-aryl-2-propen-1-ols catalyzed by quinine- derived bifunctional catalyst has been developed. The regioselectivity was controlled by employing a boronate ester as tether which was formed in situ and enantioselectivity was introduced by taking advantage of a quinine-derived bifunctional catalyst which activated the boronate ester and N-bromosuccinimide (NBS) at the same time. Chiral bromohydrin, ...