Secondary metabolites by chemical screening. 17. Nigericinol derivatives: synthesis, biological activities and modeling studies

S Grabley, P Hammann, R Klein, G Seibert…

Index: Grabley, Susanne; Hammann, Peter; Klein, Robert; Seibert, Gerhard; Winkler, Irvin; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 939 - 944

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Citation Number: 12

Abstract

The synthesis and the biological activity of C-1-reduced nigericin derivatives (nigericinols) are described and discussed. The dichloronigericinol 7 impressively demonstrated that the C-1 carboxylic acid moiety was not required for a distinct activity against bacteria and viruses. Based on the correlation between K+/H+ antiport activities and antibacterial activitiea it was deduced that the mode of action of the described nigericinols are related ...