An R??Selective Hydroxynitrile Lyase from Arabidopsis thaliana with an α/β??Hydrolase Fold

J Andexer, J von Langermann, A Mell…

Index: Andexer, Jennifer; Von Langermann, Jan; Mell, Annett; Bocola, Marco; Kragl, Udo; Eggert, Thorsten; Pohl, Martina Angewandte Chemie - International Edition, 2007 , vol. 46, # 45 p. 8679 - 8681

Full Text: HTML

Citation Number: 61

Abstract

Hydroxynitrile lyases (HNLs) catalyze the stereoselective formation of CÀC bonds between HCN and aldehydes or ketones yielding chiral cyanohydrins, which are versatile building blocks for the pharmaceutical and agrochemical industries.[1] Among the most important cyanohdrins are chiral a-hydroxy acids such as substituted mandelic acids,[1e, f, 2a] m- phenoxybenzaldehyde derivatives,[2c] and structures with additional aliphatic linkers ...