An efficient copper-catalyzed N-arylation of amides: synthesis of N-arylacrylamides and 4-amido-N-phenylbenzamides

ZJ Quan, HD Xia, Z Zhang, YX Da, XC Wang

Index: Quan, Zheng-Jun; Xia, Hai-Dong; Zhang, Zhang; Da, Yu-Xia; Wang, Xi-Cun Tetrahedron, 2013 , vol. 69, # 39 p. 8368 - 8374

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Citation Number: 13

Abstract

Abstract Copper-catalyzed intermolecular C–N bond-forming reactions between aryl iodides and amides are described using sodium ascorbate, which is both cheap and nontoxic, as the additive. A variety of functionalized amides including some practical, unique secondary amides, such as N-arylacrylamides and 4-amido-N-phenylbenzamides, which are difficult to obtain by the classical methods, are prepared. Furthermore, some tertiary amides are ...