Pyrimido [1, 6-a] benzimidazoles: a new class of DNA gyrase inhibitors

C Hubschwerlen, P Pflieger, JL Specklin…

Index: Hubschwerlen; Pflieger; Specklin; Gubernator; Gmunder; Angehrn; Kompis Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1385 - 1392

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Citation Number: 67

Abstract

Substituted 4-quinolone-(1, A= CH) and 1, 8-naphthyrid-4-one-(1, A= N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido [l, Ga] benzimihlea 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported.