Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

…, JJ Deadman, J Houghton, R McCague…

Index: Jarman; Barrie; Deadman; Houghton; McCague; Rowlands Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2452 - 2455

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Citation Number: 33

Abstract

In a search for inhibitors of 17a-hydroxyla~ eC,~,~-lyase and testosterone-5a-reductase, target enzymes in the development of drugs to treat hormone-dependent prostatic cancer, we have identified certain compounds chemically derived by the hydrolysis of decafluoroazobenzene (4) as novel inhibitors for these two enzymes. Hydrolysis of 4 gave the known 4-hydroxynonafluoroazobenzene (1) and the novel 2- ...