Inactivation of general acyl-CoA dehydrogenase by enantiomerically pure (methylenecyclopropyl) acetyl-CoA and its implication for this enzyme-catalyzed reaction

MT Lai, HW Liu

Index: Lai, Ming-Tain; Liu, Hung-Wen Journal of the American Chemical Society, 1990 , vol. 112, # 10 p. 4034 - 4035

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Citation Number: 21

Abstract

General acyl-CoA dehydrogenase (GAD) is a flavin-dependent (FAD) enzyme that catalyzes the oxidation of a fatty acyl-CoA to the corresponding a, &enolyl-CoA during the first step of the fatty acid oxidation cyc1e. l When GAD is exposed to (methy-lenecyclopropyl) acetyl- CoA (MCPA-COA),~ a metabolite of hypoglycine A which is the causative agent of the Jamaican vomiting si~ kness,~ time-dependent inhibition occurs with concomitant ...