Synthesis of indoles via palladium-catalyzed C–H activation of N-aryl amides followed by coupling with alkynes

F Zhou, X Han, X Lu

Index: Zhou, Feng; Han, Xiuling; Lu, Xiyan Tetrahedron Letters, 2011 , vol. 52, # 36 p. 4681 - 4685

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Citation Number: 36

Abstract

Molecules containing the indole nucleus are prevalent in a wide range of natural products 1 and pharmaceutical compounds. 2 Numerous procedures have been established for their preparation, most of which depend on substrate preactivation rather than readily available anilines or their derivatives as starting materials. 3 Thus, the development of new and more efficient methods is of great importance. In recent years, the construction of the indole skeleton based on ...