Synthesis of 1, 4-diphenylbutadiene derivatives: Novel inducer of tissue-type plasminogen activator (t-PA) in cultured bovine endothelial cells

H Sai, T Ogiku, H Ohmizu, A Ohtani

Index: Sai, Hiroshi; Ogiku, Tsuyoshi; Ohmizu, Hiroshi; Ohtani, Akio Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1686 - 1693

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Citation Number: 7

Abstract

(E, E)-1, 4-Diphenylbutadiene derivatives were synthesized by utilizing the Stobbe reaction of dimethyl succinate as a key step. Their stereoisomers were also synthesized stereoselectively by means of the cross-coupling reaction of the vinylstannanes and the vinylbromides, which were obtained from the propiolic acid esters by stereoselective hydrostannation, as a key step. To discover novel stimulators of fibrinolysis in vascular ...