Stereoselective total synthesis of atpenins a4 and b, harzianopyridone, and NBRI23477 B

…, S Izawa, K Shiomi, S Omura, T Nagamitsu

Index: Ohtawa, Masaki; Sugiyama, Kouhei; Hiura, Tohru; Izawa, Shujiro; Shiomi, Kazuro; Omura, Satoshi; Nagamitsu, Tohru Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 7 p. 898 - 906

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Citation Number: 4

Abstract

The stereoselective total synthesis of atpenins A4 (2) and B (3), harzianopyridone (4), and NBRI23477 B (5) have been developed using a convergent approach involving the coupling reaction of a common iodopyridine with an aldehyde corresponding to the appropriate side chain of the desired compound. Furthermore, the absolute configurations of atpenin B (3), harzianopyridone (4), and NBRI23477 B (5) have been unambiguously determined.