Palladium-catalyzed α-arylation of ketones

M Palucki, SL Buchwald

Index: Palucki; Buchwald Journal of the American Chemical Society, 1997 , vol. 119, # 45 p. 11108 - 11109

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Citation Number: 463

Abstract

The synthesis of R-aryl ketones has received much attention over the past two decades. 1 A number of stoichiometric arylating reagents have been successfully developed for this purpose; however, their utility is decreased because each synthesis of an R-aryl ketone requires the synthesis of a different arylating reagent. 2, 3 In contrast, the direct coupling of aryl halides with ketones would provide a convenient method for the synthesis of R-aryl ...