Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents

…, I Murota, K Yoshikai, S Yamada, K Yamamoto

Index: Itoh, Toshimasa; Murota, Itsuki; Yoshikai, Kazuyoshi; Yamada, Sachiko; Yamamoto, Keiko Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 1 p. 98 - 108

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Citation Number: 47

Abstract

To discover novel peroxisome proliferator-activated receptor γ (PPARγ) agonists that could be used as antidiabetic agents, we designed docosahexaenoic acid (DHA) derivatives (2 and 3), which have a hydrophilic substituent at the C (4)-position, based on the crystal structure of the ligand-binding pocket of PPARγ. These compounds were synthesized via iodolactone as a key intermediate. We found that both DHA derivatives (2 and 3) showed ...