Tetrahedron letters

DPPA-Promoted decarbonylation of a N-Cbz-(D, L)-Pipecolinic acid derivative: An easy entry to [4.5] spirolactams and [4.5] spirolactones. Total synthesis of (±)-δ- …

MJ Martin-Lopez, F Bermejo-González

Index: Martin-Lopez; Bermejo-Gonzalez Tetrahedron Letters, 1994 , vol. 35, # 24 p. 4235 - 4238

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Citation Number: 20

Abstract

Abstract The synthesis of 6-benzyloxycarbonyl-1-oxa-6-azaspiro [4.5] decane-2-one 7a and 6-benzyloxycarbonyl-1, 6-diazaspiro [4.5] decane-2-one 7b from (D, L)-pipecolinic acid is described. The extremely clean decarbonylation of the α-substituted amino acid 9d