Journal of medicinal chemistry

1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine analogs. Inactivation of monoamine oxidase by conformationally rigid analogs of N, N-dimethylcinnamylamine

CK Hiebert, RB Silverman

Index: Hiebert, Charles K.; Silverman, Richard B. Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1566 - 1570

Full Text: HTML

Citation Number: 10

Abstract

Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Euanston, Illinois 60208. Received December 14, 1987 l- Methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine (MPTP) is a potent neurotoxin and also an inactivator of monoamine oxidase (MAO). Since MPTP is a conformationally rigid analogue of N, N-dimethylcinnamylamine, other conformationally rigid analogues of N, N- ...