Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718

…, AP IJzerman, I Van Wijngaarden…

Index: Bent, Arie van der; Blommaert, Armand G. S.; Melman, Caroline T. M.; IJzerman, Adriaan P.; Wijngaarden, Ineke van; Soudijn, Willem Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1042 - 1049

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Citation Number: 23

Abstract

A series of novel nonpeptide cholecystokinin-A (CCK-A) antagonists have been synthesized. Designed on the basis of the structural homology between lorglumide and L- 364,718, as investigated with molecular modeling, these compounds constitute a link between the N-acylglutamic acid and 3-amino-5phenyl-1, 4benzodiazepin-2-one derived antagonists. The prepared compounds were tested in vitro as antagonists of the binding of ...