Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

…, F DeMorin, Y Raifeld, J Weber, F Boschelli

Index: Berger, Dan; Dutia, Minu; Powell, Dennis; Wissner, Allan; DeMorin, Frenel; Raifeld, Yuri; Weber, Jennifer; Boschelli, Frank Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2989 - 2992

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Citation Number: 40

Abstract

A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.