Synthesis and biological properties of actinomycin D chromophoric analogs substituted at carbon 7 with aziridine and cyclopropyl functions

RK Sehgal, B Almassian, DP Rosenbaum…

Index: Sehgal; Almassian; Rosenbaum; Zadrozny; Sengupta Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 790 - 793

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Citation Number: 11

Abstract

The growing importance of functionalized tricyclic rings, eg, cyclopropyl and aziridine, in numerous organic biomolecules led us to develop syntheses of novel actinomycin D (AMD) analogues substituted with aziridine and cyclopropyl functions. Reaction of 7- hydroxyactinomycin D with 1-aziridmeethyl iodide and bromomethylcyclopropane afforded the desired 7424 1-aziridiny1) ethoxyl and cyclopropylmethoxy analogues, respectively. ...