Organic letters

Palladium-catalyzed intramolecular chloroamination of alkenes

FE Michael, PA Sibbald, BM Cochran

Index: Michael, Forrest E.; Sibbald, Paul A.; Cochran, Brian M. Organic Letters, 2008 , vol. 10, # 5 p. 793 - 796

Full Text: HTML

Citation Number: 94

Abstract

A mild and facile Pd-catalyzed intramolecular chloroamination of unactivated alkenes has been described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. Generally high exo-selectivities are observed in the formation of a variety of 5-and 6-membered rings. This system is unique in its ability to tolerate multidentate ligands on palladium, which opens up the possibility of ...