The synthesis of 14-membered macrocyclic ethers

DS Clyne, L Weiler

Index: Clyne, Dean S.; Weiler, Larry Tetrahedron, 1999 , vol. 55, # 48 p. 13659 - 13682

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Citation Number: 44

Abstract

As part of an ongoing study of the chemistry of macrocyclic compounds 14-membered macrocyclic ethers with a variety of methyl substitution patterns were synthesized. The preparation of these macrocyclic ethers involved either the Baeyer-Villiger ring expansion of a cyclic ketone or the macrolactonization of a hydroxy acid to give a lactone. The lactone carbonyl was removed either by conversion to an intermediate thionolactone obtained by ...