Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for. beta.-adrenergic …

…, A ElKoussi, M Kano, T Nakamura

Index: Bodor, Nicholas; ElKoussi, Alaaeldin; Kano, Masanobu; Nakamura, Toshio Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 100 - 106

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Citation Number: 59

Abstract

Novel ketoxime analogues of known@-blockers (propranolol, timolol, carteolol) were synthesized and tested as potential site-specific chemical delivery systems. It was assumed that a hydrolysis-reduction sequence could produce the active@-blockers in the iris-ciliary body. It was found that some of these bioprecursors are remarkably active in reducing intraocular pressure in rabbits. The ketoxime derivative of propranolol is more effective ...