Synthesis and antiblastic activity of organosilicon derivatives of quinoline, isoquinoline, and N-methylpiperazine

É Lukevits, TV Lapina, ID Segal, IS Augustane…

Index: Lukevits, E.; Lapina, T. V.; Segal, I. D.; Augustane, I. S.; Verovskii, V. N. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 8 p. 619 - 623 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 8 p. 947 - 951

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Abstract

It has been shown that 4-[3-(l-silatranyl) propylamino] quinolines [I, 2], and 3-(triethylsilyl)- and 3-(l-silatranyl) propylamides of quinolinecarboxylic acids [3] possess some antiblastic activity. Continuing these studies, we have synthesized the N-substituted amides of y- trialkylsilylbutyric acids with aminoquinolines (la-f), with 1, 2, 3, 4-tetrahydroquinoline (lla, b), with 1, 2, 3, 4-tetrahydroisoquinoline (Ilia, b), and with N-methylpiperazine (Va-c), the ester ...