Tetrahedron

Directed ortho-lithiation of unprotected diphenylphosphinic acids

VY Rodríguez, MÁ del Águila, MJ Iglesias, FL Ortiz

Index: Yanez Rodriguez, Victor; Del Aguila, Miguel Angel; Iglesias, Maria Jose; Lopez Ortiz, Fernando Tetrahedron, 2012 , vol. 68, # 36 p. 7355 - 7362

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Citation Number: 23

Abstract

Directed ortho lithiation of diphenylphosphinic acid and subsequent electrophilic trapping provides mono ortho-functionalized derivatives including enantiopure γ-aminophosphinic acids in moderate yields. Copper catalyzed coupling of the ortho anion leads to biphenyl-2, 2′-diylbis (phenylphosphinic acid), a phosphorus analogue of biphenyl-2, 2′-dicarboxylic acid. Preliminary studies of the metal-binding abilities of this O, O-chelating ligand towards ...