A New Class of Local Anesthetics: Hydroxyalkyliminobisacetamides1

ME FREED, WF BRUCE…

Index: Freed,M.E. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 2378 - 2383

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Citation Number: 8

Abstract

A series of hydroxynlkyliminobkacetan~ ides and their esters was prepared and examined for local anesthetic action. The compounds derived from Na, a-trimethylphenethylamine showed a high degree of activity, some examples being 4000 times as active as procaine. Structure-activity relationships were studied in the course of this investigation.