Synthesis

Synthesis of 4-, 5-and 6-benzoylated 7-azaindoles

C Pillard, CE Bassene, F Suzenet, G Guillaumet

Index: Pillard, Christelle; Bassene, Carine Ekambome; Suzenet, Franck; Guillaumet, Gerald Synthesis, 2008 , # 13 p. 2049 - 2054

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Citation Number: 5

Abstract

Abstract Efficient syntheses of 4-, 5-and 6-benzoyl-7-azaindoles are described. Two strategies were developed: i) formation of 4-lithio and 5-lithio-7-azaindole and reaction with aldehydes and ii) organomagnesium addition to 6-cyano-7-azaindole. Both methods should allow the introduction of a diverse range of acyl substituents.