Synthesis and radioprotective activity of new cysteamine and cystamine derivatives

…, M Fatome, H Sentenac-Roumanou…

Index: Oiry, J.; Pue, J. Y.; Imbach, J. L.; Fatome, M.; Sentenac-Roumanou, H.; Lion, C. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2217 - 2225

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Citation Number: 25

Abstract

A variety of N-(aminoalkanoy1)-S-acylcysteamine and N, N-bis (aminoalkanoy1) cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S- acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N- glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structureactivity relationships are ...