DNA Binding Compounds. VI. Synthesis and Characterization of 2, 5'-Disubstituted Bibenzimidazoles Related to the DNA Minor Groove Binder Hoechst-33258

…, SA Bateman, RJ Hook, RF Martin, ME Reum…

Index: Kelly, David P.; Bateman, Stuart A.; Hook, Robert J.; Martin, Roger F.; Reum, Monica E.; et al. Australian Journal of Chemistry, 1994 , vol. 47, # 9 p. 1751 - 1770

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Citation Number: 22

Abstract

Abstract A series of compounds have been synthesized in which the basic 2- phenylbibenzimidazole structure of Hoechst 33258 has been modified to include various combinations of bromo, iodo, methoxy, amino, alkylamino and nitro groups in the terminal phenyl ring. Both sequential and convergent synthetic routes have been followed using coupling reactions of both imino ethers and aldehydes to 1, 2-diamines. All these ...