Synthesis and incorporation of the first polyketide synthase free intermediate in monocerin biosynthesis

LC Axford, TJ Simpson, CL Willis

Index: Axford, Lorraine C.; Simpson, Thomas J.; Willis, Christine L. Angewandte Chemie - International Edition, 2004 , vol. 43, # 6 p. 727 - 730

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Citation Number: 16

Abstract

Monocerin (5) is a polyketide fungal metabolite that exhibits antifungal, insecticidal, and plant pathogenic properties. It has been isolated from several fungal species, including Dreschlera monoceras,[1] D. ravenelii,[2] Exserohilum turcum,[3] and, along with the related fusarentin ethers, for example, 4, from Fusarium larvarum.[4] Polyketide metabolites are pro-