Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

…, ZY Almstead, Y Xie, J Healy, LM Buhring…

Index: Goodwin, Nicole C.; Mabon, Ross; Harrison, Bryce A.; Shadoan, Melanie K.; Almstead, Zheng Y.; Xie, Yiling; Healy, Jason; Buhring, Lindsey M.; DaCosta, Christopher M.; Bardenhagen, Jennifer; Mseeh, Faika; Liu, Qingyun; Nouraldeen, Amr; Wilson, Alan G. E.; Kimball, S. David; Powell, David R.; Rawlins, David B. Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6201 - 6204

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Citation Number: 47

Abstract

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.