Solid-phase synthesis of Smac peptidomimetics incorporating triazoloprolines and biarylalanines

ST Le Quement, M Ishoey, MT Petersen…

Index: Le Quement, Sebastian T.; Ishoey, Mette; Petersen, Mette T.; Thastrup, Jacob; Hagel, Grith; Nielsen, Thomas E. ACS Combinatorial Science, 2011 , vol. 13, # 6 p. 667 - 675

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Citation Number: 10

Abstract

Apoptotic induction mechanisms are of crucial importance for the general homeostasis of multicellular organisms. In cancer the apoptotic pathways are downregulated, which, at least partly, is due to an abundance of inhibitors of apoptosis proteins (IAPs) that block the apoptotic cascade by deactivating proteolytic caspases. The Smac protein has an antagonistic effect on IAPs, thus providing structural clues for the synthesis of new pro- ...

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The epidemiology of sepsis in the United States from 1979 through 2000

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