A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron emitting …

…, MR Kilbourn, JA Katzenellenbogen…

Index: Chi, Dae Yoon; Kilbourn, Michael R.; Katzenellenbogen, John A.; Welch, Michael J. Journal of Organic Chemistry, 1987 , vol. 52, # 4 p. 658 - 664

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Citation Number: 109

Abstract

We have described a two-step method for the preparation of fluoroalkyl-substituted amines and amides. The sequence involves fluoride ion displacement of a haloalkyl trifluoromethanesulfonate (triflate), followed by fluoroalkylation of the heteroatom system (amine or amide) by the fluoroalkyl halide. Alternatively, the fluoroalkyl halide can be prepared by halofluorination of a terminal olefin. These reactions have been used to ...